Circadian Rhythm-Aligned Antioxidant Delivery: A Non-Invasive Strategy to Combat Oxidative Stress in Indian Adults
DOI:
https://doi.org/10.56450/JEFI.2025.v3i02.009Keywords:
Circadian Rhythm, Antioxidants, Oxidative Stress, Non-Invasive Therapy, Indian AdultsAbstract
Introduction: Oxidative stress contributes to chronic diseases like diabetes, cardiovascular ailments, and neurodegenerative conditions, which are common among Indian adults. Aligning antioxidant administration with biological circadian rhythms may offer a promising, non-invasive intervention strategy (1,2). Methodology: This cross-sectional observational study was conducted between January and June 2024 and enrolled 1,000 Indian adults aged 30–60 years from urban and rural areas. Participants were randomized into two groups: Group A received Vitamin C and E at circadian-optimized timings, while Group B received them at fixed standard times. Oxidative stress biomarkers were assessed via salivary assays. Statistical analysis was performed in May 2024 using SPSS (p<0.05 considered significant). Results: Group A showed significantly reduced levels of malondialdehyde (1.85 ± 0.23 µmol/L) compared to Group B (2.32 ± 0.27 µmol/L, p<0.001), and higher total antioxidant capacity (1.67 ± 0.14 vs. 1.42 ± 0.15 mmol/L, p<0.001). Discussion: Chronotherapy-based antioxidant delivery was found effective in reducing oxidative stress markers. This supports its potential as a cost-effective, personalized intervention for lifestyle-related conditions.
Downloads
References
1. World Health Organization. Global status report on noncommunicable diseases 2014. Geneva: WHO; 2014.
2. Smolensky MH, Lemmer B, Reinberg A. Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma. Adv Drug Deliv Rev. 2007;59(9-10):852-82.
3. Sies H. Oxidative stress: from basic research to clinical application. Am J Med. 1991;91(3C):31S-38S.
4. Panda S. Circadian physiology of metabolism. Science. 2016;354(6315):1008-15.
5. Hardeland R. Melatonin and oxidative stress: from molecular mechanisms to clinical practice. Cell Mol Life Sci. 2005;62(7-8):791-808.
6. Gupta R, Guptha S, Sharma KK. Prevalence of cardiovascular disease risk factors in Indian adolescents. Indian J Pediatr. 2012;79(12):1641-1645.
7. Reiter RJ, Tan DX, Galano A. Melatonin: exceeding expectations. Physiology. 2014;29(5):325-333.
8. Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature. 2002;418(6901):935-941.
9. Cermakian N, Sassone-Corsi P. Multilevel regulation of the circadian clock. Nat Rev Mol Cell Biol. 2000;1(1):59-67.
10. Gachon F, Nagoshi E, Brown SA, et al. The mammalian circadian timing system: from gene expression to physiology. Chromosoma. 2004;113(3):103-112.
11. Arendt J. Melatonin and human rhythms. Chronobiol Int. 2006;23(1-2):21-37.
12. Partch CL, Green CB, Takahashi JS. Molecular architecture of the mammalian circadian clock. Trends Cell Biol. 2014;24(2):90-99.
13. Bonnefont X, Raynaud F, Lacassagne E, et al. Circadian rhythms in liver metabolism and pathology. Compr Physiol. 2014;4(2):1395-1430.
14. Sharma M, Mishra S, Mishra V. Role of antioxidants in Indian dietary practices. J Clin Nutr Diet. 2019;5(2):1-6.
15. Buijs RM, Kalsbeek A. Hypothalamic integration of clocks. Nat Rev Neurosci. 2001;2(7):521-526.
16. Tan DX, Hardeland R. Melatonin and brain protection. Indian J Med Res. 2014;139(6):851-857.
17. Gangwisch JE. Sleep duration and hypertension. Am J Hypertens. 2014;27(10):1235-1242.
18. Atkinson G, Reilly T. Circadian variation in sports performance. Sports Med. 1996;21(4):292-312.
19. Arble DM, Bass J, Behn CD, et al. Circadian disruption and diabetes. Obesity. 2015;23(2):292-294.
20. Rao S, Shah S, Mohapatra A. Antioxidant therapy in metabolic syndrome. Indian J Clin Biochem. 2018;33(3):318-325.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Dinesh Reddy Sagam (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
This means that you are free to:
- Share, copy, and redistribute the article in any medium or format
- Adapt, remix, transform, and build upon the article
as long as you provide appropriate credit to the original work, include the authors' names, article title, journal name, and indicate that the work is licensed under CC BY. Any use of the material should not imply endorsement by the authors or the journal.
