Evaluation of prevalence, predisposing factors, inter-species differences in clinical profile and outcome of Campylobacter blood-stream infections: A 7-year experience from north India
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https://doi.org/10.56450/JEFI.2024.v2i03.008Keywords:
Blood Culture, Bacteraemia, Infections in Immunosuppressed, Epidemiology, Campylobacter FetusIssue
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Copyright (c) 2024 Megha Sharma, Sivanantham Krishnamoorthi, PRIYA V S, Sanjay Verma, Sudesh Rana, Lakhan Pal, Archana Angrup, Pallab Ray
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Purpose: A comprehensive study evaluating prevalence, risk factors and outcome of Campylobacter bloodstream infection (CBSI) in Indian population is lacking. Methods: A retrospective analysis of blood culture specimens positive for Campylobacter species over a 7-year period (September 2013 to August 2020) was conducted. Campylobacter species were identified using MALDI-TOF MS and patients’ details were retrieved from hospital records. Results: 39 episodes from 38 patients were reported (0.15% of all BSI), with one case of recurrence. The median age was 10 years. 54.5% patients presented with gastrointestinal symptoms. Steroid-dependent nephrotic syndrome predisposed paediatric patients (27.3%) and liver cirrhosis predisposed adult patients (81.8%) to CBSI. Conclusion: C. jejuni was the most prevalent species (59%) followed by C. coli (25.6%) and C. fetus (15.4%). C. fetus infection was seen in immunocompetent patients (p=0.01) and was associated with longer hospital stay (p=0.01). Overall outcome of CBSI was good.Abstract
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Megha Sharma, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Sivanantham Krishnamoorthi, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Priya Sreenivasan, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Sanjay Verma, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Sudesh Rana, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Lakhan Pal, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Archana Angrup, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Pallab Ray, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Kendall ME, Crim S, Fullerton K, Han P V., Cronquist AB, Shiferaw B, et al. Travel-associated enteric infections diagnosed after return to the united states, foodborne diseases active surveillance network (FoodNet), 2004-2009. Clin Infect Dis. 2012;54(SUPPL.5). Platts-Mills JA, Kosek M. Update on the burden of Campylobacter in developing countries. Curr Opin Infect Dis. 2014;27(5):444–50. Hussein K, Raz-Pasteur A, Shachor-Meyouhas Y, Geffen Y, Oren I, Paul M, et al. Campylobacter bacteraemia: 16 years of experience in a single centre. Infect Dis (Auckl). 2016;48(11–12):796–9. Nielsen H, Hansen KK, Gradel KO, Kristensen B, Ejlertsen T, Østergaard C, et al. Bacteraemia as a result of Campylobacter species: A population-based study of epidemiology and clinical risk factors. Clin Microbiol Infect. 2010;16(1):57–61. Silva J, Leite D, Fernandes M, Mena C, Gibbs PA, Teixeira P. Campylobacter spp. As a foodborne pathogen: A review. Front Microbiol. 2011;2(SEP):1–12. Feodoroff B, Lauhio A, Ellström P, Rautelin H. A nationwide study of campylobacter jejuni and campylobacter coli bacteremia in Finland over a 10-year period, 1998-2007, with special reference to clinical characteristics and antimicrobial susceptibility. Clin Infect Dis. 2011;53(8):e99–106. Fernández-Cruz A, Muñoz P, Mohedano R, Valerio M, Marín M, Alcalá L, et al. Campylobacter Bacteremia: Clinical Characteristics, Incidence, and Outcome Over 23 Years. Medicine (Baltimore). 2010;89(5):319–30. Harvala H, Ydring E, Brytting M, Söderblom T, Mäkitalo B, Wallensten A, et al. Increased number of Campylobacter bacteraemia cases in Sweden, 2014. Clin Microbiol Infect [Internet]. 2016;22(4):391–3. Available from: http://dx.doi.org/10.1016/j.cmi.2015.11.013 Liao CH, Chuang CY, Huang YT, Lee PI, Hsueh PR. Bacteremia caused by antimicrobial resistant Campylobacter species at a medical center in Taiwan, 1998-2008. J Infect [Internet]. 2012;65(5):392–9. Available from: http://dx.doi.org/10.1016/j.jinf.2012.06.014 O’Hara GA, Fitchett JRA, Klein JL. Campylobacter bacteremia in London: A 44-year single-center study. Diagn Microbiol Infect Dis [Internet]. 2017;89(1):67–71. Available from: http://dx.doi.org/10.1016/j.diagmicrobio.2017.05.015 Pacanowski J, Lalande V, Lacombe K, Boudraa C, Lesprit P, Legrand P, et al. Campylobacter bacteremia: Clinical features and factors associated with fatal outcome. Clin Infect Dis. 2008;47(6):790–6. Tasaka K, Matsubara K, Nigami H, Iwata A, Isome K, Yamamoto G. Invasive Campylobacter jejuni/coli Infections: 9 Case Reports at a Single Center between 2000 and 2015, and a Review of Literature Describing Japanese Patients. Kansenshogaku Zasshi. 2016;90(3):297–304. Fica C A, Porte T L, Braun J S, Veas P N, Pavez A C, Dabanch P J, et al. Bacteriemias e infección endovascular por Campylobacter spp: nuestra experiencia en un cuarto de siglo de historia. Rev Chil infectología. 2011;28(3):211–6. Liu YH, Yamazaki W, Huang YT, Liao CH, Sheng WH, Hsueh PR. Clinical and microbiological characteristics of patients with bacteremia caused by Campylobacter species with an emphasis on the subspecies of C. fetus. J Microbiol Immunol Infect [Internet]. 2019;52(1):122–31. Available from: https://doi.org/10.1016/j.jmii.2017.07.009 Ben-Shimol S, Carmi A, Greenberg D. Demographic and clinical characteristics of campylobacter bacteremia in children with and without predisposing factors. Pediatr Infect Dis J. 2013;32(11):414–8. Sharma M, Gautam V, Mahajan M, Rana S, Majumdar M, Ray P. Direct identification by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) from positive blood culture bottles: An opportunity to customize growth conditions for fastidious organisms causing bloodstream infections. Indian J Med Res [Internet]. 2017;146:541–4. Available from: http://www.journalonweb.com/ijmr Mori T, Hasegawa N, Sugita K, Shinjoh M, Nakamoto N, Shimizu T, et al. Clinical features of bacteremia due to Campylobacter jejuni. Intern Med. 2014;53(17):1941–4. Weinberger M, Lerner L, Valinsky L, Moran-Gilad J, Nissan I, Agmon V, et al. Increased incidence of Campylobacter spp. infection and high rates among children, Israel. Emerg Infect Dis. 2013;19(11):1828–31. Kim Y, Shin JA, Han SB, Cho B, Jeong DC, Kang JH, et al. Recurrent Campylobacter jejuni bacteremia in a patient with hypogammaglobulinemia: A case report. Med (United States). 2017;96(25):18–20. Kirk KF, Nielsen HL, Nielsen H. The susceptibility of Campylobacter concisus to the bactericidal effects of normal human serum. Apmis. 2015;123(3):269–74. Ge MC, Kuo SF, Chang SC, Chien CC, You HL, Lu JJ. Antimicrobial susceptibility and virulence surveillance of Campylobacterspp. isolated from patients in two tertiary medical centers in Taiwan. Front Microbiol. 2019;10(01):1–9. Pigrau C, Bartolome R, Almirante B, Planes A, Gavalda J, Pahissa A. Bacteremia Due to Campylobacter Species : Clinical Findings and Antimicrobial Susceptibility Patterns. 1996;1414–20. van der Beek MT, Claas ECJ, Mevius DJ, van Pelt W, Wagenaar JA, Kuijper EJ. Inaccuracy of routine susceptibility tests for detection of erythromycin resistance of Campylobacter jejuni and Campylobacter coli. Clin Microbiol Infect [Internet]. 2010;16(1):51–6. Available from: http://dx.doi.org/10.1111/j.1469-0691.2009.02755.x Clinical and Laboratory Standards Institute (CLSI). Methods for Antimicrobial Dilution and Disk Susceptibility Testing of Infrequently Isolated or Fastidious Bacteria. 3rd ed. CLSI guideline M45. 2016;(ISBN 1-56)
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