Sibling Anesthesiologists Plead For Pathogen Reduction/ Inactivation Technologies Acting On Whole Blood And Its Components/ Products To Counter Transfusion Transmissible/ Transmitted Infections/ Pathogens Locally, Regionally And Globally
DOI:
https://doi.org/10.56450/JEFI.2025.v3i04.010Abstract
The time is very ripe to futuristically aim globally for potential sterilization-before-transfusion of donated whole blood and its components/products with uniform and potentially mandatory inclusion of pathogen reduction/inactivation technologies thereafter evolving to potentially make current screening questions asked from blood donors and current laboratory tests performed on blood donations as byline/postscript.
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1. Mammen JJ, Asirvatham ES, Lakshmanan J, Sarman CJ, Pandey A, Ranjan V, Charles B, Mani T, Khaparde SD, Upadhyaya S, Rajan S. The clinical demand and supply of blood in India: A National level estimation study. PLoS One. 2022 Apr 6;17(4):e0265951. doi: 10.1371/journal.pone.0265951. https://pmc.ncbi.nlm.nih.gov/articles/PMC8986005/ Last accessed July 30, 2025
2. Sachdev S, Mittal K, Patidar G, Marwaha N, Sharma RR, Duseja AK, Chawla YK, Arora SK. Risk Factors for Transfusion Transmissible Infections Elicited on Post Donation Counselling in Blood Donors: Need to Strengthen Pre-donation Counselling. Indian J Hematol Blood Transfus. 2015 Sep;31(3):378-84. doi: 10.1007/s12288-014-0460-7. https://pmc.ncbi.nlm.nih.gov/articles/PMC4465512/ Last accessed July 30, 2025
3. Deshmukh S, Rathod Y, Thakore S, Jadhav S. Prevalence of Transfusion-Transmissible Infections Among Voluntary Blood Donors in a Tertiary Care Hospital. Cureus. 2024 Sep 29;16(9):e70469. doi: 10.7759/cureus.70469. https://pmc.ncbi.nlm.nih.gov/articles/PMC11524599/ Last accessed July 30, 2025
4. Ahmadpour E, Foroutan-Rad M, Majidiani H, Moghaddam SM, Hatam-Nahavandi K, Hosseini SA, Rahimi MT, Barac A, Rubino S, Zarean M, Mathioudakis AG, Cevik M. Transfusion-Transmitted Malaria: A Systematic Review and Meta-analysis. Open Forum Infect Dis. 2019 Jun 11;6(7):ofz283. doi: 10.1093/ofid/ofz283. Erratum in: Open Forum Infect Dis. 2020 Jan 24;7(1):ofz540. doi: 10.1093/ofid/ofz540. https://pmc.ncbi.nlm.nih.gov/articles/PMC6634438/ Last accessed July 30, 2025
5. Kitchen AD, Chiodini PL. Malaria and blood transfusion. Vox Sang. 2006 Feb;90(2):77-84. doi: 10.1111/j.1423-0410.2006.00733.x. https://onlinelibrary.wiley.com/doi/10.1111/j.1423-0410.2006.00733.x Last accessed July 30, 2025
6. Verra F, Angheben A, Martello E, Giorli G, Perandin F, Bisoffi Z. A systematic review of transfusion-transmitted malaria in non-endemic areas. Malar J. 2018 Jan 16;17(1):36. doi: 10.1186/s12936-018-2181-0. https://malariajournal.biomedcentral.com/articles/10.1186/s12936-018-2181-0 Last accessed July 30, 2025
7. Prevalence of Transfusion Transmissible Infections and Associated Factors among Healthy Blood Donors in North Indian Population – 4-Year Experience of Licensed Blood Bank at Tertiary Care Hospital https://journals.lww.com/jmsc/fulltext/2022/24001/prevalence_of_transfusion_transmissible_infections.10.aspx Last accessed July 30, 2025
8. Gebreyes DS, Kifetew K, Gizaw A, Abebe TA, Shenkutie TT, Genetu D, Yitayew B, Hailu A. Prevalence and Risk Factors of Transfusion-Transmissible Infections Among Voluntary Blood Donors in North Shoa, Amhara Region, Ethiopia: A Cross-Sectional Study. Health Sci Rep. 2025 May 5;8(5):e70769. doi: 10.1002/hsr2.70769. https://pmc.ncbi.nlm.nih.gov/articles/PMC12051436/ Last accessed July 30, 2025
9. Cwinyaai N, Opio D, Kajumbula H, Zalwango JF, Akunzirwe R, Okello T, Francis A. Prevalence and Factors Associated with transfusion-transmissible infections among blood donors in Arua regional blood bank, Uganda. BMC Infect Dis. 2024 Sep 6;24(1):926. doi: 10.1186/s12879-024-09838-4. https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09838-4 Last accessed July 30, 2025
10. Riley W, Love K, Saxon M, Tobian A, Bloch EM, Kasirye R, Lubega I, Musisi E, Dhabangi A, Kyeyune D, McCullough J. A Model for Estimating the Burden of Disease of Transfusion-Transmitted Infection. Int J Public Health. 2024 Aug 6;69:1607165. doi: 10.3389/ijph.2024.1607165. https://pmc.ncbi.nlm.nih.gov/articles/PMC11333201/ Last accessed July 30, 2025
11. GLOBAL STATUS REPORT ON BLOOD SAFETY AND AVAILABILITY 2021 https://iris.who.int/bitstream/handle/10665/356165/9789240051683-eng.pdf Last accessed July 30, 2025
12. Global Database on Blood Safety https://www.who.int/teams/health-product-policy-and-standards/standards-and-specifications/blood-and-products-of-human-origin/quality-and-safety/global-database-on-blood-safety Last accessed July 30, 2025
13. Transfusion-transmitted Infections https://www.dynamed.com/condition/transfusion-transmitted-infections Last accessed July 30, 2025
14. Viewpoint: Why blood transfusions are still giving Indians HIV https://www.bbc.com/news/world-asia-india-36457517 Last accessed July 30, 2025
15. India hospital transfusions infect thousands with HIV https://www.bbc.com/news/world-asia-india-36417789 Last accessed July 30, 2025
16. Eligibility Criteria: Alphabetical https://www.redcrossblood.org/donate-blood/how-to-donate/eligibility-requirements/eligibility-criteria-alphabetical.html Last accessed July 30, 2025
17. Who can give blood https://www.who.int/campaigns/world-blood-donor-day/2018/who-can-give-blood Last accessed July 30, 2025
18. Blood Services https://www.indianredcross.org/ircs/program/BloodBank/ Last accessed July 30, 2025
19. Why Donate Blood https://eraktkosh.mohfw.gov.in/BLDAHIMS/bloodbank/donateblood.cnt Last accessed July 30, 2025
20. Blood Transfusion Services /National Blood Transfusion Council https://dghs.mohfw.gov.in/bts.php Last accessed July 30, 2025
21. Recommendations to Reduce the Risk of Transfusion-Transmitted Malaria: Draft Guidance for Industry January 2025 https://www.fda.gov/regulatory-information/search-fda-guidance-documents/recommendations-reduce-risk-transfusion-transmitted-malaria-0 Last accessed July 30, 2025
22. FDA POLICY CONSIDERATIONS FOR TESTING BLOOD DONATIONS FOR MALARIA https://www.fda.gov/media/178522/download Last accessed July 30, 2025
23. FDA Malaria Draft Guidance for Blood Centers Available https://americasblood.org/abc-newsletter/fda-malaria-draft-guidance-for-blood-centers-available/ Last accessed July 30, 2025
24. Transfusion-Transmitted Malaria in the United States https://www.fda.gov/media/178526/download Last accessed July 30, 2025
25. Blood Donor Screening https://www.cdc.gov/malaria/screening/index.html Last accessed July 30, 2025
26. Recommendations for Evaluating Donor Eligibility Using Individual Risk-Based Questions to Reduce the Risk of Human Immunodeficiency Virus Transmission by Blood and Blood Products: Guidance for Industry May 2023 https://www.fda.gov/regulatory-information/search-fda-guidance-documents/recommendations-evaluating-donor-eligibility-using-individual-risk-based-questions-reduce-risk-human Last accessed July 30, 2025
27. Recommendations for Evaluating Donor Eligibility Using Individual Risk-Based Questions to Reduce the Risk of Human Immunodeficiency Virus Transmission by Blood and Blood Products: Guidance for Industry https://www.fda.gov/media/164829/download Last accessed July 30, 2025
28. Flegel WA. Pathogen-reduction technology, good in more than one way for cellular blood components, is replacing irradiation. Transfus Apher Sci. 2025 Apr;64(2):104088. doi: 10.1016/j.transci.2025.104088. https://www.sciencedirect.com/science/article/abs/pii/S1473050225000229 Last accessed July 30, 2025
29. Kwon SY, Kim IS, Bae JE, Kang JW, Cho YJ, Cho NS, Lee SW. Pathogen inactivation efficacy of Mirasol PRT System and Intercept Blood System for non-leucoreduced platelet-rich plasma-derived platelets suspended in plasma. Vox Sang. 2014 Oct;107(3):254-60. doi: 10.1111/vox.12158. https://onlinelibrary.wiley.com/doi/epdf/10.1111/vox.12158 Last accessed July 30, 2025
30. Piccin A, Allameddine A, Spizzo G, Lappin KM, Prati D. Platelet Pathogen Reduction Technology-Should We Stay or Should We Go…? J Clin Med. 2024 Sep 10;13(18):5359. doi: 10.3390/jcm13185359. https://www.mdpi.com/2077-0383/13/18/5359 Last accessed July 30, 2025
31. Arcas Otero C, Pereira Saavedra A, Castrillo Fernández A, Vilariño López MD. Comparison of transfusion-outcome in patients with massive bleeding receiving pathogen-reduced platelets prepared with two different technologies. Transfus Apher Sci. 2022 Jun;61(3):103359. doi: 10.1016/j.transci.2022.103359. https://www.sciencedirect.com/science/article/abs/pii/S147305022200009X Last accessed July 30, 2025
32. Pathogen inactivation of blood products https://www.uptodate.com/contents/pathogen-inactivation-of-blood-products Last accessed July 30, 2025
33. Mirasol Pathogen Reduction Technology https://www.terumobct.com/en/gl/products-services/global-blood-solutions/global-blood-solutions-products/mirasol.html Last accessed July 30, 2025
34. Advances in Pathogen Reduction Technologies to Improve Global Transfusion Safety https://www.clinicallab.com/advances-in-pathogen-reduction-technologies-to-improve-global-transfusion-safety-26534 Last accessed July 30, 2025
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Copyright (c) 2026 Divya Gupta, Deepak Gupta (Author)
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